Go to homepage
     
Home
Who we are
>company profile
>career opportunities
>mission and pledge
>caring for community
What we do
>Oral Health Care
>Biotechnology
R & D
  > Oral Health Diagnostics
       >Gingivitis
    
>Halitosis
    
>Periodontitis
  >Neurodegenerative Diagnostic
Product
  >Nucleotide Photoaffinity Labeling
What's New
  >In the News
Contact Us
  >order products
  >Customer Service
  >Licensing Opportunities
  >Human Resources
  >Investment Opportunities


Possible Alzheimer's Diagnostic

A blood diagnostic test for Alzheimer's Disease (AD) and potentially other neurodegenerative diseases is in research and development. The development of the technology is supported by continuing NIH grants for over 25 years and is based on the detection of an enzyme (glutamine synthetase or GS) that is released from the brain during the progression of AD and Lou Gehrig's disease (ALS). The technology allows for detection of enzyme and protein differences found in serum and cerebrospinal fluid of normal verses diseased subjects. The detection of GS by photoaffinity labeling was reported as a potential diagnostic test for AD and published in the 1992 Proceeding of the National Academy of Science (PNAS).

The University of Kentucky patented the technology and it is exclusively licensed to ALT BioScience™. The PNAS publication led to an increased use of Nucleotide Photoaffinity Labeling Technology as an important research tool for developing diagnostic testing procedures and led other researchers to the confirmation of the Alzheimer's protein as a biomarker to be relatively specific and elevated in only one other neurological disease, Lou Gehrig's or ALS (amyotrophic lateral).

Clinical co-development with phased drug discovery, clinical efficacy of current therapeutics or diagnostics for AD or other forms of dementia, ALS, or Schizophrenia are areas of ongoing and future research. ALT BioScience™ is a CLIA licensed laboratory.
Photomodified Antibodies
 

ALT BioScience™ has a discovery method for photoinserting compounds into specific sites on antibodies without loss of antigen recognition. Also published in the PNAS, the process is successful in incorporating radioactivity, biotin, anticancer drugs and other small compounds of importance into antibodies. This technology has the ability to rapidly produce antibodies that are more sensitive for diagnostic procedures and for therapeutic uses such as cancer cell specific antibodies, which contain high levels of the radioactive species 32 P and 33 P phosphate. The cancer cell derived antibodies containing these radioactive species are widely believed to be one of the best developments for treating solid tumors.

Co-development opportunities exist for the development of an active laboratory for optimization or modification of antibodies for use in diagnosis and therapeutic treatments. Others have reported the production of "Super Antibodies" using ALT BioScience's™ technology that involves photo-insertion of a small peptide that allows internalization of the antibody that is directed toward an intracellular protein involved in growth and is specific for cancer cells. ALT BioScience™ currently has the technology to readily test and modify other antibodies for multiple approaches, including internalization.