ALT
BioScience™ has a discovery method for
photoinserting compounds into specific
sites on antibodies without loss of antigen
recognition.
Also published in the PNAS, the process
is successful in incorporating radioactivity,
biotin, anticancer drugs and other small
compounds of importance into antibodies.
This technology has the ability to rapidly
produce antibodies that are more sensitive
for diagnostic procedures and for therapeutic
uses such as cancer cell specific antibodies,
which contain high levels of the radioactive
species 32 P and 33 P phosphate. The cancer
cell derived antibodies containing these
radioactive species are widely believed
to be one of the best developments for
treating solid tumors.
Co-development opportunities
exist for the development of an active
laboratory
for optimization or modification of antibodies
for use in diagnosis and therapeutic treatments.
Others have reported the production of "Super
Antibodies" using ALT BioScience's™ technology
that involves photo-insertion of a small
peptide that allows internalization of
the antibody that is directed toward
an intracellular
protein involved in growth and is specific
for cancer cells. ALT BioScience™ currently
has the technology to readily test and
modify other antibodies for multiple
approaches,
including internalization. |